MicroNMR Technical Support

Conference Presentations

ENC 2008 Abstract - Structure Elucidation of Oligosaccharides

ENC 2005 Abstract 233 NMR Probe Comparison

ENC 2005 Abstract 237 Direct Carbon NMR

ENC 2005 Abstract 330 Modified DNA NMR Studies

ENC 2005 Abstract 387 Ultra-High Throughput NMR

ENC 2005 Abstract 389 Natural Products NMR

ENC 2005 Poster DNA Mismatch Analysis by Monique Cosman

SMASH 2008 Poster: "Chasing Structures in the Drug Delivery Process", R. Boetzel, A. Codina and K. Mackay

SMASH 2008 Poster: "Knowing More and More About... ", T. Burrow, R. Enriquez, D. McNally, and W. Reynolds

SMASH 2008 - MRM - Abstract - Workflow Diagram

SMASH 2008 - MRM - Poster - MedChem

SMASH 2008 - MRM - Poster - Metabolomics

Journal Papers

Technical Advances: Method, Workflow and Productivity

Evolving Trends in the Dereplication of Natural Product Extracts: New Methodology for Rapid, Small-Scale Investigation of Natural Product Extracts

Gerhard Lang, Nor Ainy Mayhudin, Maya I. Mitova, Lin Sun, Sonia van der Sar, John W. Blunt, Anthony L. J. Cole, Gill Ellis, Hartmut Laatsch, and Murray H. G. Munro

J. Nat. Prod. 2008 , 71(9), 1595-1599.

High-Throughput Natural Product Chemistry Methods and the Application of the Capillary NMR Probe

Jinfeng Hu, Gary R. Eldridge, Yihua Yu, Mark O’Neil-Johnson

Progress in Chemistry (China) 2008, 20(4), 429-440.

Optimized liquid chromatography-mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance

Gaetan Glauser, Davy Guillarme, Elia Grata, Julien Boccard, Aly Thiocone, Pierre-Alain Carrupt, Jean-Luc Veuthey, Serge Rudaz, Jean-Luc Wolfender

Journal of Chromatography A:2008, 1180, 90-98. (NMR part is discussed in the paper)

UPLC-TOF-MS for Plant Metabolomics: A Powerful Tool for Discriminating Stress States in Plants and Detecting Low-Level Wound Biomarkers

Glauser G., Grata E., Boccard J., Marsden-Edwards E., Major H., Carrupt P.-A., Rudaz S., and Wolfender J.-L.

American Laboratory, On-line Edition:Jun 2008, Posted On: 6/27/2008. (Focused on LC-MS)

Development of Ultrahigh-Throughput NMR Spectroscopic Analysis Utilizing Capillary Flow NMR Technology

Nigel J. C. Bailey and Ian R. Marshall

Analytical Chemistry 2005, 77, 3947-3953.

Synthesis Chemistry

Determination of regulatory phosphorylation sites in nanogram amounts of a synthetic fragment of ZAP-70 using microprobe NMR and on-line coupled capillary HPLC-NMR

Petra Hentschel, Manfred Krucker, Marc David Grynbaum, Karsten Putzbach, Rainer Bischoff, Klaus Albert

Magn. Reson. Chem. 2005; 43: 747-754

Metabolomics/Metabonomics

Optimized liquid chromatography-mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance

Gaetan Glauser, Davy Guillarme, Elia Grata, Julien Boccard, Aly Thiocone, Pierre-Alain Carrupt, Jean-Luc Veuthey, Serge Rudaz, Jean-Luc Wolfender

Journal of Chromatography A:2008, 1180, 90-98. (NMR part is discussed in the paper)

UPLC-TOF-MS for Plant Metabolomics: A Powerful Tool for Discriminating Stress States in Plants and Detecting Low-Level Wound Biomarkers

Glauser G., Grata E., Boccard J., Marsden-Edwards E., Major H., Carrupt P.-A., Rudaz S., and Wolfender J.-L.

American Laboratory, On-line Edition:Jun 2008, Posted On: 6/27/2008. (Focused on LC-MS)

Differential Analysis of Mycoalexins in Confrontation Zones of Grapevine Fungal Pathogens by Ultrahigh Pressure Liquid Chromatography/Time-of-Flight Mass Spectrometry and Capillary Nuclear Magnetic Resonance

Glauser G., Gindro K., Fringeli J., de Joffrey J.-P., Rudaz S., and Wolfender J.-L.

Journal of Agricultural and Food Chemistry 2009, 57, 1127-1134

Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics

Kunle Odunsi, Robert M. Wollman, Christine B. Ambrosone, Alan Hutson, Susan E. McCann, Jonathan Tammela, John P. Geisler, Gregory Miller, Thomas Sellers, William Cliby, Feng Qian, Bernadette Keitz, Marilyn Intengan, Shashikant Lele and James L. Alderfer

Int. J. Cancer:2005, 113, 782-788.

NMR-Based Metabonomic approaches for evaluating Biofluids

Mary E. Bollard, Elizabeth G. Stanley, John C. Lindon, Jeremy K. Nicholson, and Elaine Holmes

NMR Biomed. 2005; 18: 143-162.

Direct on-line hyphenation of capillary liquid chromatography to nuclear magnetic resonance spectroscopy: Practical aspects and application to drug metabolite identification

Martin Sandvoss, Andy D. Roberts, Ismail M. Ismail and Stephanie E. North

Journal of Chromatography A 2004, 1028(2), 259-266.

Medicinal Chemistry

Automated Microflow NMR: Routine Analysis of Five-Microliter Samples

Ariane Jansma, Tiffany Chuan, Robert W. Albrecht, Dean L. Olson, Timothy L. Peck, and Bernhard H. Geierstanger

Anal. Chem.; 2005; 77, 6509-6515.

Natural Products

Evolving Trends in the Dereplication of Natural Product Extracts: New Methodology for Rapid, Small-Scale Investigation of Natural Product Extracts

Gerhard Lang, Nor Ainy Mayhudin, Maya I. Mitova, Lin Sun, Sonia van der Sar, John W. Blunt, Anthony L. J. Cole, Gill Ellis, Hartmut Laatsch, and Murray H. G. Munro

J. Nat. Prod. 2008 , 71(9), 1595-1599.

Identification of Natural Products Using HPLC-SPE Combined with CapNMR

Maja Lambert, Jean-Luc Wolfender, Dan Stærk, S. Brogger Christensen, Kurt Hostettmann, and Jerzy W. Jaroszewski

Analytical Chemistry 2007, 79, 727-735.

Stilbenes from the Orchid Phragmipedium sp.

Eliane Garo, Jin-Feng Hu, Grayson W. Hough, Matt G. Goering, Mark O'Neil-Johnson, and Gary Eldridge

Journal of Natural Products, 2007, 70, 968-973.

Laxanol, a new 2,5-diaryl-3,4-dihydroxymethyltetrahydrofuran type lignan from Justicia laxa.

Hu, J.F., Starks, C., Garo, E., Hough, G., Rice, S., Goering, M.G., O'Neil-Johnson, M., Eldridge, G.R.

Journal of Chemical Research, 2008, 1, 20-21.

Acuminatanol, the first 2',2'''-bis-dihydrobiflavonol from the Aqueous Extract of Trichoscypha acuminata

Hu, J.F.; Garo, E.; Hough, G.; Goering, M.; O’Neil-Johnson, M.; Eldridge, G.R.

Tetrahedron Letters, 2007, 48, 5747-5749

Isoflavones from Psorothamnus arborescens via High-throughput Natural Product Chemistry Methods

Hu, J.F.; Garo, E.; Hough, G.; Goering, M.; Yoo, H.D; O’Neil-Johnson, M.; Eldridge, G.R.

Journal of Chemical Research, 2007, 5, 296-297

Anti-HCV Bioactivity of Pseudoguaianolides from Parthenium hispitum.

Jin-Feng Hu, R. Patel, B. Li, Elaine Garo, Grayson Hough, Matt Goering, Hye-Dong Yoo, Mark O'Neil-Johnson, and Gary Eldridge

Journal of Natural Products, 2007, 70, 604-607.

The importance of hyphenated techniques in the discovery of new lead compounds from nature

Jean-Luc Wolfender, Emerson Ferreira Queiroz and Kurt Hostettmann

Expert Opin. Drug Discov. 2006, 1(3), 237-260.

spiro-Mamakone A: A Unique Relative of the Spirobisnaphthalene Class of Compounds

Sonia A. van der Sar, John W. Blunt, and Murray H. G. Munro

Organic Letters; 2006; 8(10) 2059-2061.

Structure elucidation of deoxylutein II isomers by on-line capillary high performance liquid chromatography-1H nuclear magnetic resonance spectroscopy

Petra Hentschel, Marc David Grynbaum, Péter Molnár, Karsten Putzbach, Jens Rehbein, József Deli and Klaus Albert

Journal of Chromatography A 2006, 1112 (1-2), 285-292.

Antibacterial, Partially Acetylated Oligorhamnosides from Cleistopholis patens.

Jin-Feng Hu , Elaine Garo, G.W. Hough, Matt G. Goering, Mark O'Neil-Johnson, and Gary R. Eldridge

Journal of Natural Products. 2006, 69, 585-590.

Bacterial Biofilm Inhibitors from Diospyros dendo

Jin-Feng Hu, Eliane Garo, Matt G. Goering, Mark Pasmore, Hye-Dong Yoo, Tim Esser, Jennifer Sestrich, Peadar A. Cremin, Grayson W. Hough, Peter Perrone, Yin-Shi L. Lee, Ngoc-Tram Le, Mark O'Neil-Johnson, John W. Costerton, and Gary R. Eldridge

Journal of Natural Products 2006, 69, 118-120.

Phytochemistry in the microgram domain - a LC-NMR perspective

Jean-Luc Wolfender, Emerson F. Queiroz, Kurt Hostettmann

Magn. Reson. Chem. 2005; 43: 697-709.

Application of capillary-scale NMR for the structure determination of phytochemicals.

Jin-Feng Hu, Eliane Garo, Hye-Dong Yoo, Peadar A. Cremin, Lu Zeng, Matt G. Goering, Mark O'Neil-Johnson and Gary R. Eldridge

Phytochem. Anal. 2005, 16, 127-133.

Capillary liquid chromatography-microcoil 1H nuclear magnetic resonance spectroscopy and liquid chromatography-ion trap mass spectrometry for on-line structure elucidation of isoflavones in Radix astragali

H.B. Xiao, M. Krucker, K. Putzbach and K. Albert.

Journal of Chromatography A 2005, 1067, (1-2), 135-143.

Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods

Jin-Feng Hu , Eliane Garo, Hye-Dong Yoo, Peadar A. Cremin, Matt G. Goering, Mark O'Neil-Johnson and Gary R. Eldridge

Phytochemistry 2005, 66(9), 1077-1082.

Suaveolindole, a New Mass-Limited Antibacterial Indolosesquiterpene from Greenwayodendron suaveolens Obtained via High-Throughput Natural Products Chemistry Methods

Hye-Dong Yoo, Peadar A. Cremin, Lu Zeng, Eliane Garo, Caroline T. Williams, Chris M. Lee, Matt G. Goering, Mark O'Neil-Johnson, Gary R. Eldridge, and Jin-Feng Hu

Journal of Natural Products 2005; 68 (1), 122-124,

Exploring Uncharted Terrain in Nature's Structure Space Using Capillary NMR Spectroscopy: 13 Steroids from 50 Fireflies

Matthew Gronquist, Jerrold Meinwald, Thomas Eisner, and Frank C. Schroeder

J. Am. Chem. Soc.; 2005; 127(31) 10810-10811.

LC-NMR coupling technology: recent advancements and applications in natural products analysis

Vassiliki Exarchou, Manfred Krucker, Teris A. van Beek, Jacques Vervoort, Ioannis P. Gerothanassis, Klaus Albert

Magn. Reson. Chem. 2005, 43, 681-687.

Miniaturization of the Structure Elucidation of Novel Natural Products - Two Trace Antibacterial Acylated Caprylic Alcohol Glycosides from Arctostaphylos pumila

Jin-Feng Hu, Hye-Dong Yoo, Caroline T. Williams, Eliane Garo, Peadar A. Cremin, Lu Zeng, Hélène C. Vervoort, Chris M. Lee, Shane M. Hart, Matt G. Goering, Mark O'Neil-Johnson, and Gary R. Eldridge

Planta Med. 2005, 71, 176-180.F

Unambiguous detection of astaxanthin and astaxanthin fatty acid esters in krill (Euphausia superba Dana)

Marc David Grynbaum, Petra Hentschel, Karsten Putzbach, Jens Rehbein, Manfred Krucker, Graeme Nicholson, Klaus Albert

Journal of Separation Science 2005, 28, 1685-1693.

Hyphenation of capillary high-performance liquid chromatography to microcoil magnetic resonance spectroscopy determination of various carotenoids in a small-sized spinach sample

Karsten Putzbach, Manfred Krucker, Marc David Grynbaum, Petra Hentschel, Andrew G. Webb and Klaus Albert

Journal of Pharmaceutical and Biomedical Analysis 2005, 38, 910-917.

Hyphenation of Capillary HPLC to Microcoil 1H NMR Spectroscopy for the Determination of Tocopherol Homologues

Manfred Krucker, Annette Lienau, Karsten Putzbach, Marc David Grynbaum, Paul Schuler, and Klaus Albert

Analytical Chemistry 2004, 76, 2623-2628.

High Throughput Method for Natural Products Library

Gary R. Eldridge, Hélène C. Vervoort, Chris M. Lee, Peadar A. Cremin, Caroline T. Williams, Shane M. Hart, Matt G. Goering, Mark O'Neil-Johnson, and Lu Zeng

Analytical Chemistry 2002, 74, 3963-3971.

Separations

Insights into cyclodextrin interactions during sample stacking using capillary isotachophoresis with on-line microcoil NMR detection

Valentino K. Almeida and Cynthia K. Larive

Magn. Reson. Chem. 2005; 43: 755-761.

Food Science

Structure Determination of Partially Deuterated Carotenoids from Intrinsically Labeled Vegetables by HPLC-MS and 1H NMR

Karsten Putzbach, Manfred Krucker, Klaus Albert, Michael A. Grusak, Guangwen Tang, and Gregory G. Dolnikowski

J. Agric. Food Chem. 2005, 53, 671-677.

Proteomics

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR

Wolfgang Peti, Rebecca Page, Kin Moy, Mark O'Neil-Johnson, Ian A. Wilson, Raymond C. Stevens and Kurt Wüthrich

Journal of Structural and Functional Genomics; 2005; 6(4), 259-267.

Biomolecular NMR Using a Microcoil NMR Probe - New Technique for the Chemical Shift Assignment of Aromatic Side Chains in Proteins

Wolfgang Peti, James Norcross, Gary Eldridge, and Mark O'Neil-Johnson

J. Am. Chem. Soc. 2004, 124, 5873-5878.

Microflow NMR Technology Reviews

Extending the Scope of NMR Spectroscopy with Microcoil Probes

Frank C. Schroeder and Matthew Gronquist

Angewandte Chemie International Edition 2006, 45(43), 7122-7131.

Nuclear magnetic resonance coupled microseparations

Andrew G. Webb

Magn. Reson. Chem. 2005; 43: 688-696.

A comparison of capillary-scale LC-NMR with alternative techniques: spectroscopic and practical considerations

Richard J. Lewis, Michael A. Bernstein, Sara J. Duncan, Chris J. Sleigh

Magn. Reson. Chem. 2005; 43: 783-789.

Use of Microcoil Probes to Acquire More Sensitive NMR Spectral Data

Peter Froehlich

American Laboratory 2005, 54-58.

Microflow NMR: Concepts and Capabilities

Dean L. Olson, James A. Norcross, Mark O'Neil-Johnson, Paul F. Molitor, David J. Detlefsen, Aaron G. Wilson, and Timothy L. Peck

Analytical Chemistry 2004, 76, 2966-2974