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Dr. Steve Hollis - Automating Quantitative NMR using OneMinuteNMR(tm) and Cryo-flow

posted Oct 26, 2012, 1:32 PM by Craig Milling

5 Oct 2011Dr. Steve Hollis currently works at Amgen in Boston. Prior to Amgen, Steve spent many years just north of our probe facility in Illinois at Abbott Laboratories. Steve has been a long time customer of Protasis, and has purchased several systems while both at Abbott and at Amgen. Steve approached Protasis about a year ago with the desire to use Microflow automation to load cold probes using a flowcell insert, in order to push the ultimate limits of sensitivity for high-throughput structure verification. The results have been nothing short of remarkable.

This recording was made at a seminar at the lab of Dr. Roger Kautz in Northeastern University (Boston, MA).

Dr Dean Olson - OneMinuteNMR(tm) in the Undergraduate Teaching Lab

posted Oct 26, 2012, 1:29 PM by Craig Milling

28 April 2011 - In this presentation, Dr. Dean L. Olson, Director of the NMR Lab, School of Chemical Sciences, University of Illinois at Urbana-Champaign, talks about his supervision of more than 200 students/semester in their use of the Protasis OneMinuteNMR(tm) and CapNMR(tm) Probe in CHEM 237 - the undergraduate, organic chemistry lab.  This system has made simple the submission of student-synthesized samples, and has improved data quality and consistency to the point where student data are now integrated into classroom discussions.

Dr Tom O'Connell - Applications of Micro-Scale NMR for Metabolomics

posted Oct 26, 2012, 1:23 PM by Craig Milling

8 March, 2011 - In this 1-hour e-seminar Dr. Tom O'Connell (then Assoc. Prof. in the Division of Pharmacotherapy and Experimental Therapeutics at the Univ. of North Carolina Chapel Hill School of Pharmacy and Director of the UNC-Hamner Institutes Metabolomics Laboratory, currently at Liposcience, Inc.) describes the application of Protasis NMR automation to the expanding field of metabolomics. Protasis' One-Minute NMR™ automation system and CapNMR™ probe are designed to reliably and with high mass-sensitivity analyze small aliquots of precious sample, making practical metabolomics investigations of biofluids in small animals (e.g. mice). Work in the UNC laboratory spans the translational research spectrum from cell and animal models all the way through clinical trials. Specific projects include investigation of the link between environmental arsenic exposure and diabetes, and the study of drug-induced liver injury.

Dr. Ke Ruan - Automated Structure Verification using the Dual Sample Probe (tm)

posted Oct 23, 2012, 11:22 AM by Craig Milling

Feb, 2010 - Dr. Ke Ruan, then resident at the Pfizer, Chesterfield (St. Louis) research facility. Dr. Ruan, in conjunction with Dr. Claude Jones, developed a high throughput method of structure verification using the Protasis Dual Sample Probe and advanced Hadamard pulse sequences.

Dr Jean-Luc Wolfender - LC-MS + CapNMR in Plant

posted Oct 23, 2012, 11:16 AM by Craig Milling

9 Feb, 2009 - Prof. Jean-Luc Wolfender of the University of Geneva provides an update of his research results in the arena of plant metabolomics. Professor Wolfender is affiliated with the Laboratory of Pharmacognosy and Phytochemistry in the Department of Pharmaceutical Sciences at the University of Geneva, and has won both the Egon Stahl award (Society for Medicinal Plant research) and the International award of the Belgian Society of Pharmaceutical Sciences. His primary work involves new methodologies for studying metabolic variations induced by stress or genetic modifications in plants, and specifically the search for new signaling molecules using A. thaliana as a model. Professor Wolfender has been a CapNMR probe user since 2004.

Prof. John Blunt - Rapid Dereplication of Bioactive Extracts

posted Oct 23, 2012, 11:10 AM by Craig Milling

Dec, 2008 - Emeritus Professor John Blunt is recently retired as co-leader (with Murray H G Munro) of the Marine Chemistry group at the University of Canterbury. The focus of this group is on the isolation and characterization of novel biologically-active metabolites from marine invertebrates and fungi. Once identified, the compounds are subjected to chemical modifications to establish structure-activity relationships. Professors Blunt and Munro have developed and maintained a bibliographic database (MarinLit and AntiMarin) of the marine natural products literature. In this e-seminar Dr. Blunt reports on his research and specifically the incorporation of NMR analysis into the process of dereplication.

Dr. Anna Codina - Cap and CASE: a step forward towards automatic structure elucidation

posted Oct 11, 2012, 4:33 AM by Craig Milling   [ updated Oct 11, 2012, 1:33 PM ]

Nov 8, 2008 - The e-seminar below features Dr. Anna Codina, then resident at the Pfizer Ltd, Sandwich (UK) research facility.  The seminar details investigations into modern approaches to elucidation involving NMR.  Prior to Pfizer, Dr. Codina had affiliation with the Laboratory of Molecular Biology Medical Research Council in Cambridge, UK - a cornerstone of biological systems and molecular structure advances.  

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